Transplantation of an adrenal cortical carcinoma.

One reference to the transplantation of an adrenal cortical tumor of the mouse has been found in the literature. Dalton, Edwards, and Andervont (1) reported on a spontaneous, transplantable, adrenal cortical tumor in a female strain C mouse 24 89 months of age. They presented evidence that this neoplasm originated from relatively undifferentiated cells of the adrenal cortex. The failure to find metastases from the original growth or the transplanted tumors suggested that the neoplasm was relatively benign in character. However, the rapid growth rate attained in later generations plus invasion of the capsule indicated a certain degree of malignancy. Careful examination for gross and histologic changes, particularly in the urogenital system and adrenal glands, was made. In female hosts focal edema was noted in the deeper layers 9f the endometrial stroma of the uterus; no changes were noted in the genital system of male hosts.